Scientific research

Proven by science.

Nasal photobiomodulation is not a theory. Three independent clinical studies, published in peer-reviewed medical journals, document its effectiveness on allergic rhinitis and chronic sinusitis.

published studies

72%

max improvement

26 years

of clinical evidence

Note: The studies presented relate to nasal photobiomodulation in general. Rubience is based on this research but has not been the subject of its own clinical trials. This information is provided for educational purposes and does not constitute medical advice.

Study 1 Double-blind randomised controlled trial

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Narrow-band red light phototherapy in perennial allergic rhinitis and nasal polyposis

Annals of Allergy, Asthma & Immunology 1997 60 participants

Neuman I, Finkelstein Y

72%

of treated patients reported symptom improvement

70%

objective improvement confirmed by nasendoscopy

24%

only in the placebo group

Longueur d'onde 660 nm

Durée 14 jours

Methodology

Double-blind randomised controlled trial. 50 allergic rhinitis patients + 10 nasal polyposis. Treatment: 660 nm red light for 4.4 minutes, 3 times daily over 14 days (6 joules/day). Assessment by symptom score and video nasendoscopy before/after.

Key results

660 nm red light produces a clear attenuation of clinical symptoms in patients with uncomplicated allergic rhinitis. The improvement is statistically significant compared to placebo on both criteria (symptoms and endoscopy).

Narrow-band 660 nm rhinophototherapy constitutes an effective treatment for allergic rhinitis. The authors recommend prior endoscopic screening to identify suitable candidates.

Study 2 Clinical pilot study

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Pilot study on the effect of low-level laser therapy in patients with chronic rhinosinusitis

Physiotherapy Theory and Practice 2013 15 adults

Naghdi S, Nakhostin Ansari N, Fathali M, Bartley J, Varedi M, Honarpishe R

46%

improvement in total symptom score at 4 weeks

39%

improvement from week 2 of treatment

5 months

average duration of benefits after stopping

Longueur d'onde 830 nm

Durée 4 semaines

Methodology

Pre/post-test clinical pilot study on 15 adults with chronic rhinosinusitis. Ga-Al-As laser 830 nm, 30 mW, 1 joule per application point on 6 points (maxillary and frontal sinuses). 3 sessions per week, 10 sessions total. Assessment by total symptom score (TSS) at baseline, 2 weeks and 4 weeks post-treatment.

Key results

TSS improvement is 39% at 2 weeks and reaches 46.34% at 4 weeks, with a large effect size. Therapeutic benefits persist for an average of 5 months after the end of treatment.

Low-level laser treatment produces substantial improvement in chronic rhinosinusitis symptoms. The authors conclude on the clinical effectiveness of the approach for this indication.

Study 3 Prospective clinical study

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Effects of rhinophototherapy combining visible and infrared light in patients with allergic rhinitis

American Journal of Rhinology & Allergy 2023 Allergic rhinitis patients

Koycu A, Bas C, Musabak UH, Erbek SS, Koca HS, Babakurban ST, Bahcecitapar M

7/7

symptom criteria improved in a statistically significant way

4 wks

of treatment sufficient for measurable improvement

2023

most recent study confirming clinical effectiveness

Longueur d'onde Visible + infrarouge

Durée 4 semaines

Methodology

4-week prospective study. Intranasal rhinophototherapy combining visible and infrared light. Weekly measurement of symptoms (nasal itching, discharge, obstruction, sneezing, eyes, throat, ears). Nasal wash samples before/after treatment, analysed by flow cytometry.

Key results

All symptom scores show statistically significant improvement from baseline. At the cellular level, rhinophototherapy significantly modifies neutrophil and eosinophil populations in the nasal mucosa, confirming a direct anti-inflammatory mechanism of action.

Four weeks of intranasal rhinophototherapy combining visible and infrared light produce measurable clinical improvements in patients with allergic rhinitis, representing a viable alternative to conventional medications.

Science-based

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